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Jouko Kärkelä, M.D. (Ph.D.), Consultant Anaesthetist

Independent researcher and author








1.   J.Kärkelä: Biochemical markers in hypoxic brain injury. A prospective clinical  study.  Acta Universitatis Tamperensis ser A vol 369. Tampere 1993. ISBN  951-44-3362-9. THESIS


1.1.    J. Odink, J. Kärkelä, J.T.N.M. Thissen and K-M. Marnela: Biogenic amine metabolites in human CSF after hypoxia due to cardiac arrest. Acta Neurol Scand 1989:80:6-11.


1.2.    J. Kärkelä and M. Scheinin: Tryptophan and biogenic amine metabolites in postmortem human cisternal fluid: effects of post-mortem interval and agonal time. J Neurol Sci 1992:107:239-245.


1.3.    J. Kärkelä, M. Pasanen, S. Kaukinen, P. Mörsky and A. Harmoinen: Evaluation of hypoxic brain injury with spinal fluid enzymes, lactate and pyruvate. Crit Care Med 1992:20:378-386.


1.4.    J. Kärkelä, K-M. Marnela, J. Odink, T. Koivula and S. Kaukinen: Amino acids and glucose in cerebrospinal fluid after acute ischaemic brain damage. Resuscitation 1992:23:145-156.


1.5.    J. Kärkelä: Critical evaluation of post mortem changes in human autopsy cisternal fluid. Enzymes, electrolytes, acid-base balance, glucose and glycolysis, free amino acids and ammonia. Correlation to total brain ischemia. J Forensic Sci 1993:38:603-616.


1.6.    J. Kärkelä, E. Bock and S. Kaukinen: CSF and serum brain specific creatine kinase isoenzyme (CK-BB), neuron specific enolase (NSE) and neural cell adhesion molecule (NCAM) as prognostic markers for hypoxic brain injury after cardiac arrest in man. J Neurol Sci 1993:116:100-109.



1. M. Oikkonen, J. Kärkelä and T. Seppälä: CSF concentrations and clinical effects following intravenous dixyrazine premedication. Eur J Clin Pharmacol 1995:47:445-447.


2. L. Kaukinen, H. Porkkala, S.Kaukinen, E. Pehkonen, J. Karkela, RK Aaran and M. Tarkka: Release of brain-specific creatine kinase and neuron specific enolase into cerebrospinal fluid  after hypothermic and normothermic cardiopulmonary bypass in coronary artery surgery. Acta Anaesth. Scand 2000:44 (4):361-368



3. J. Kärkelä, O. Vakkuri, S. Kaukinen, W-Q. Huang and M. Pasanen: The  influence of  anaesthesia and surgery on the circadian rhythm of melatonin.  Acta Anaesth. Scand 2002:46:30-36





 1. J. Kärkelä, S. Kaukinen, K-M. Marnela, J. Kataja and T. Koivula: Biochemical changes in cerebrospinal fluid after acute hypoxic brain damage. Publications of the research institute of Åbo Akademi foundation nr. 120. Proceedings of the IV meeting of Finnish Neurochemists Turku 5th and 6th of June, 1986, Åbo 1986:83-84.


 2. Marnela K-M, Kärkelä J, Kataja J and Kaukinen S: Free amino acids in cerebrospinal fluid after acute hypoxic brain damage (poster). European Society for Neurochemistry. Sixth General Meeting. September 1-6, Prague 1986


 3. Eerola R, Kärkelä J, Marnela K-M, Kaukinen S, Kataja J, Koivula T: Biochemical changes in cerebrospinal fluid  induced by acute brain hypoxia. International symposium “Results and prospects of the development of modern reanimatology” Devoted to the 50th anniversary of the AMSci USSR. September 16-18, Moscow 1986. Abstracts: 142


 4. Kärkelä J, Kaukinen S, Marnela K-M, Koivula T: Biochemical changes of the cerebrospinal fluid caused by acute brain hypoxia (poster). The annual meeting of Nordisk Förening för Neuroanestesi och Neurologisk Intensivbehandlung (NNAF). A joint-meeting with the Finnish Association of Anaesthesiologists. November 8th , Helsinki/Töölö Hospital 1986


 5. Odink J, Kärkelä J, Thissen JTNM, Marnela K-M: Biogenic amine metabolites in human cerebrospinal fluid after hypoxic brain damage (poster). 6th international cathecholamine symposium. June 14-19, Jerusalem 1987.


 6. J. Kärkelä, S. Kaukinen, E. Seppälä, H. Wuorela and H. Vapaatalo: Cerebrospinal fluid prostanoids, cAMP and enzymes after acute hypoxic brain damage. Pharmacology & Toxicology 1987:60 (suppl. III):52.


 7. Eerola R, Kärkelä J, Marnela K-M, Kaukinen S, Kataja J, Koivula T: Prognostic value of changes in some biochemical parameters of cerebrospinal fluid in acute cerebral hypoxia. Anesteziol. / Reanimatol. (Moscow) 1988; 1:39-41


 8. J. Kärkelä: Free amino acids and ammonia in postmortem cerebrospinal fluid (CSF) (poster). XXXI International congress of physiological sciences. July 9-14, Helsinki, Finland, 1989. Abstracts: P 5233.


 9. J. Kärkelä: Biochemical markers in hypoxic brain injury. A prospective clinical study. Acta Anaesthesiol Scand 1994:38:410.


10. J. Kärkelä: Biochemical markers in hypoxic brain injury. A prospective clinical study. Acta Universitatis Tamperensis ser A vol 369. ISBN 951-44-3362-9. Abstract of the doctoral dissertation for publication in DAI-C [Dissertation abstracts international (section C)] 1993.


11. L. Kaukinen, H. Peltoniemi, S. Kaukinen, J. Kärkelä, R-K. Aaran, E. Pehkonen and M. Tarkka: Neurological recovery and cerebrospinal fluid enzymes after normothermic (NTCPB) and hypothermic (HTCPB) cardiopulmonary bypass. Br J Anaesth 1995:74 (suppl 2):48 (Abstracts:A.93).